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poetry
569 IssuesPython packaging and dependency management made easy
(python-poetry/poetry)liberapay.com
543 IssuesSource code of the recurrent donations platform Liberapay
(liberapay/liberapay.com)scanpy
539 IssuesSingle-cell analysis in Python. Scales to >1M cells.
(scverse/scanpy)pyvista
528 Issues3D plotting and mesh analysis through a streamlined interface for the Visualization Toolkit (VTK)
(pyvista/pyvista)zarr-python
528 IssuesAn implementation of chunked, compressed, N-dimensional arrays for Python.
(zarr-developers/zarr-python)tortoise-orm
524 IssuesFamiliar asyncio ORM for python, built with relations in mind
(tortoise/tortoise-orm)pymc
510 IssuesBayesian Modeling in Python
(pymc-devs/pymc)pyqtgraph
509 IssuesFast data visualization and GUI tools for scientific / engineering applications
(pyqtgraph/pyqtgraph)fabric
509 IssuesSimple, Pythonic remote execution and deployment.
(fabric/fabric)django
509 IssuesThe Web framework for perfectionists with deadlines.
(django/django)adk-python
504 IssuesAn open-source, code-first Python toolkit for building, evaluating, and deploying sophisticated AI agents with flexibility and control.
(google/adk-python)python
503 IssuesMy Python Examples
(geekcomputers/python)manim
501 IssuesAnimation engine for explanatory math videos
(3b1b/manim)mitmproxy
496 IssuesAn interactive TLS-capable intercepting HTTP proxy for penetration testers and software developers.
(mitmproxy/mitmproxy)yt
493 IssuesMain yt repository
(yt-project/yt)weblate
492 IssuesWeb based translation tool with tight version control integration.
(weblateorg/weblate)integrations-core
487 IssuesCore integrations of the datadog agent
(datadog/integrations-core)evalai
483 Issues:cloud: :rocket: :bar_chart: :chart_with_upwards_trend: Evaluating state of the art in AI
(cloud-cv/evalai)aim
478 IssuesAim 💫 — An easy-to-use & supercharged open-source experiment tracker.
(aimhubio/aim)marker
475 IssuesConvert PDF to markdown + JSON quickly with high accuracy
(datalab-to/marker)rez
462 IssuesAn integrated package configuration, build and deployment system for software
(academysoftwarefoundation/rez)thefuck
461 IssuesMagnificent app which corrects your previous console command.
(nvbn/thefuck)guake
459 IssuesDrop-down terminal for GNOME
(guake/guake)cognee
459 IssuesMemory for AI Agents in 5 lines of code
(topoteretes/cognee)nose
451 Issuesnose is nicer testing for python
(nose-devs/nose)experimenter
440 IssuesA web application for managing user experiments for Mozilla Firefox.
(mozilla/experimenter)gensim
440 IssuesTopic Modelling for Humans
(piskvorky/gensim)dash
433 IssuesData Apps & Dashboards for Python. No JavaScript Required.
(plotly/dash)gpytorch
423 IssuesA highly efficient implementation of Gaussian Processes in PyTorch
(cornellius-gp/gpytorch)django-tastypie
411 IssuesCreating delicious APIs for Django apps since 2010.
(django-tastypie/django-tastypie)pygithub
410 IssuesTyped interactions with the GitHub API v3
(jacquev6/pygithub)pygithub
408 IssuesTyped interactions with the GitHub API v3
(pygithub/pygithub)readthedocs.org
399 IssuesThe source code that powers readthedocs.org
(readthedocs/readthedocs.org)studio
391 IssuesContent curation tools for Kolibri
(learningequality/studio)prowler
386 IssuesProwler is the Open Cloud Security platform for AWS, Azure, GCP, Kubernetes, M365 and more. It helps for continuous monitoring, security assessments & audits, incident response, compliance, hardening and forensics readiness. Includes CIS, NIST 800, NIST C
(prowler-cloud/prowler)rdflib
385 IssuesRDFLib is a Python library for working with RDF, a simple yet powerful language for representing information.
(rdflib/rdflib)minigpt-4
376 IssuesOpen-sourced codes for MiniGPT-4 and MiniGPT-v2 (https://minigpt-4.github.io, https://minigpt-v2.github.io/)
(vision-cair/minigpt-4)flask-restplus
368 IssuesFully featured framework for fast, easy and documented API development with Flask
(noirbizarre/flask-restplus)bernstein
365 IssuesDeterministic orchestrator for 30+ CLI AI coding agents. Git worktree isolation, HMAC audit trail, MCP server mode.
(sipyourdrink-ltd/bernstein)plasmapy
348 IssuesA community developed python package for plasma physics in the early stages of development.
(plasmapy/plasmapy)scrapy
347 IssuesScrapy, a fast high-level web crawling & scraping framework for Python.
(scrapy/scrapy)text
346 IssuesModels, data loaders and abstractions for language processing, powered by PyTorch
(pytorch/text)couchers
344 IssuesCouchers.org
(couchers-org/couchers)h5py
343 IssuesHDF5 for Python -- The h5py package is a Pythonic interface to the HDF5 binary data format.
(h5py/h5py)anyway
342 IssuesANYWAY - Car accidents map
(data-for-change/anyway)antenna
341 IssuesAn online toolset to manage and analyze data collected from insect camera traps for research and conservation efforts.
(rolnicklab/antenna)audio
340 IssuesData manipulation and transformation for audio signal processing, powered by PyTorch
(pytorch/audio)trio
331 IssuesTrio – a friendly Python library for async concurrency and I/O
(python-trio/trio)preswald
330 IssuesPreswald is a WASM packager for Python-based interactive data apps: bundle full complex data workflows, particularly visualizations, into single files, runnable completely in-browser, using Pyodide, DuckDB, Pandas, and Plotly, Matplotlib, etc. Build dashb
(structuredlabs/preswald)autokey
328 IssuesAutoKey, a desktop automation utility for Linux and X11.
(autokey/autokey)