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bleachbit
316 IssuesBleachBit system cleaner for Windows and Linux
(bleachbit/bleachbit)lutris
316 IssuesLutris desktop client in Python / PyGObject
(lutris/lutris)sqlmesh
312 IssuesEfficient data transformation and modeling framework that is backwards compatible with dbt.
(tobikodata/sqlmesh)optimum
309 Issues🚀 Accelerate training and inference of 🤗 Transformers and 🤗 Diffusers with easy to use hardware optimization tools
(huggingface/optimum)saleor
307 IssuesSaleor Core: the high performance, composable, headless commerce API.
(saleor/saleor)red-discordbot
304 IssuesA multifunction Discord bot
(cog-creators/red-discordbot)aiohttp
300 IssuesAsynchronous HTTP client/server framework for asyncio and Python
(aio-libs/aiohttp)autokey
297 IssuesAutoKey, a desktop automation utility for Linux and X11.
(autokey/autokey)mackup
293 IssuesKeep your application settings in sync (OS X/Linux)
(lra/mackup)bottle
287 Issuesbottle.py is a fast and simple micro-framework for python web-applications.
(bottlepy/bottle)tldr
285 Issues:books: Simplified and community-driven man pages
(tldr-pages/tldr)urllib3
280 Issuesurllib3 is a user-friendly HTTP client library for Python
(urllib3/urllib3)psutil
279 IssuesCross-platform lib for process and system monitoring in Python
(giampaolo/psutil)aeon
278 IssuesA toolkit for machine learning from time series
(aeon-toolkit/aeon)copyparty
275 IssuesPortable file server with accelerated resumable uploads, dedup, WebDAV, FTP, TFTP, zeroconf, media indexer, thumbnails++ all in one file, no deps
(9001/copyparty)superagi
275 Issues<⚡️> SuperAGI - A dev-first open source autonomous AI agent framework. Enabling developers to build, manage & run useful autonomous agents quickly and reliably.
(transformeroptimus/superagi)mmpretrain
273 IssuesOpenMMLab Pre-training Toolbox and Benchmark
(open-mmlab/mmpretrain)black
272 IssuesThe uncompromising Python code formatter
(psf/black)augur
271 IssuesPipeline components for real-time phylodynamic analysis
(nextstrain/augur)yournextrepresentative
271 Issues👥 A website for crowd-sourcing structured election candidate data
(democracyclub/yournextrepresentative)bandit
267 IssuesBandit is a tool designed to find common security issues in Python code.
(pycqa/bandit)netbox
266 IssuesThe premier source of truth powering network automation. Open source under Apache 2. Public demo: https://demo.netbox.dev
(netbox-community/netbox)netbox
266 IssuesIP address management (IPAM) and data center infrastructure management (DCIM) tool.
(digitalocean/netbox)spacy
266 Issues💫 Industrial-strength Natural Language Processing (NLP) with Python and Cython
(explosion/spacy)bernstein
265 IssuesDeterministic orchestrator for 30+ CLI AI coding agents. Git worktree isolation, HMAC audit trail, MCP server mode.
(sipyourdrink-ltd/bernstein)keras
263 IssuesDeep Learning for humans
(keras-team/keras) (microsoft/taskmatrix)taskmatrix
262 Issuesversatile-data-kit
259 IssuesOne framework to develop, deploy and operate data workflows with Python and SQL.
(vmware/versatile-data-kit)seaborn
254 IssuesStatistical data visualization in Python
(mwaskom/seaborn)timesketch
251 IssuesCollaborative forensic timeline analysis
(google/timesketch)requests
251 IssuesA simple, yet elegant HTTP library.
(psf/requests)requests
251 IssuesPython HTTP Requests for Humans™ ✨🍰✨
(requests/requests)prisma-client-py
250 IssuesPrisma Client Python is an auto-generated and fully type-safe database client designed for ease of use
(robertcraigie/prisma-client-py)beancount
248 IssuesBeancount: Double-Entry Accounting from Text Files.
(beancount/beancount)simple-salesforce
247 IssuesA very simple Salesforce.com REST API client for Python
(simple-salesforce/simple-salesforce)cppcoreguidelines
247 IssuesThe C++ Core Guidelines are a set of tried-and-true guidelines, rules, and best practices about coding in C++
(isocpp/cppcoreguidelines)num2words
246 IssuesModules to convert numbers to words. 42 --> forty-two
(savoirfairelinux/num2words)investpy
244 Issuesinvestpy — is a Python library for historical data extraction from the spanish stock market
(alvarob96/investpy)investpy
244 IssuesFinancial Data Extraction from Investing.com with Python
(alvarobartt/investpy)pdfminer
243 IssuesPython PDF Parser (Not actively maintained). Check out pdfminer.six.
(euske/pdfminer)deepagents
238 IssuesDeep Agents is an agent harness built on langchain and langgraph. Deep Agents are equipped with a planning tool, a filesystem backend, and the ability to spawn subagents - making them well-equipped to handle complex agentic tasks.
(langchain-ai/deepagents)nltk
234 IssuesNLTK Source
(nltk/nltk)mypaint
230 IssuesMyPaint is a simple drawing and painting program that works well with Wacom-style graphics tablets.
(mypaint/mypaint)django-extensions
228 IssuesThis is a repository for collecting global custom management extensions for the Django Framework.
(django-extensions/django-extensions)ignite
228 IssuesHigh-level library to help with training and evaluating neural networks in PyTorch flexibly and transparently.
(pytorch/ignite)python-fire
227 IssuesPython Fire is a library for automatically generating command line interfaces (CLIs) from absolutely any Python object.
(google/python-fire)vintageous
227 IssuesVi/Vim emulation for Sublime Text 3
(guillermooo/vintageous)dvc
227 Issues🦉 Data Version Control | Git for Data & Models | ML Experiments Management
(iterative/dvc)tornado
227 IssuesTornado is a Python web framework and asynchronous networking library, originally developed at FriendFeed.
(tornadoweb/tornado)aiconfig
222 IssuesAIConfig is a config-based framework to build generative AI applications.
(lastmile-ai/aiconfig)