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fastapi
57 IssuesFastAPI framework, high performance, easy to learn, fast to code, ready for production
(tiangolo/fastapi)dask-jobqueue
57 IssuesDeploy Dask on job schedulers like PBS, SLURM, and SGE
(dask/dask-jobqueue)great_expectations
57 IssuesAlways know what to expect from your data.
(great-expectations/great_expectations)webpy
56 Issuesweb.py is a web framework for python that is as simple as it is powerful.
(webpy/webpy)doberman-core
56 IssuesYour AI's guard dog. Doberman sits at runtime, gating every input, output and tool call to stop unsafe or unintended actions before they execute.
(dobermancore/doberman-core)clippy-vision
56 IssuesFully local AI assistant that watches your screen to eliminate the context problem. No cloud. No data leakage.
(protocorn/clippy-vision)python-chess
55 IssuesA chess library for Python, with move generation and validation, PGN parsing and writing, Polyglot opening book reading, Gaviota tablebase probing, Syzygy tablebase probing, and UCI/XBoard engine communication
(niklasf/python-chess)flask-testing
54 IssuesUnittest extensions for Flask
(jarus/flask-testing)argopy
54 IssuesA python library for Argo data beginners and experts
(euroargodev/argopy)django-unicorn
53 IssuesThe magical reactive component framework for Django ✨
(adamghill/django-unicorn)opendevops
53 IssuesCODO是一款为用户提供企业多混合云、一站式DevOps、自动化运维、完全开源的云管理平台、自动化运维平台
(opendevops-cn/opendevops)tribler
53 IssuesPrivacy enhanced BitTorrent client with P2P content discovery
(tribler/tribler)fabulously-optimized
53 IssuesA Fabric-based modpack for Minecraft that focuses on performance and graphics optimizations
(fabulously-optimized/fabulously-optimized) (opensearch-project/opensearch-py-ml)opensearch-py-ml
52 Issuescommunity.crypto
52 IssuesThe community.crypto collection for Ansible.
(ansible-collections/community.crypto)hololinked
52 IssuesZMQ-based RPC with HTTP support for SCADA applications in python
(vigneshvsv/hololinked)fpdf2
52 IssuesSimple PDF generation for Python
(py-pdf/fpdf2)inky
52 IssuesCombined library for V2/V3 Inky pHAT and Inky wHAT.
(pimoroni/inky)hypothesis-python
51 IssuesHypothesis is a powerful, flexible, and easy to use library for property-based testing.
(hypothesisworks/hypothesis-python)hypothesis
51 IssuesHypothesis is a powerful, flexible, and easy to use library for property-based testing.
(hypothesisworks/hypothesis)zenpy
50 IssuesPython wrapper for the Zendesk API
(facetoe/zenpy)spectroscopyx
49 IssuesA community developed python package for spectroscopy.
(plasmapy/spectroscopyx)openai-agents-python
49 IssuesA lightweight, powerful framework for multi-agent workflows
(openai/openai-agents-python)gym-duckietown
48 IssuesSelf-driving car simulator for the Duckietown universe
(duckietown/gym-duckietown)unitypack
48 IssuesPython deserialization library for Unity3D Asset format
(hearthsim/unitypack) (sivenchinniah/pokemanki)pokemanki
48 Issuesjsons
48 Issues🐍 A Python lib for (de)serializing Python objects to/from JSON
(ramonhagenaars/jsons)rapidsms
48 IssuesBuild SMS applications with Python
(rapidsms/rapidsms)typer
48 IssuesTyper, build great CLIs. Easy to code. Based on Python type hints.
(tiangolo/typer)drf-nested-routers
47 IssuesNested Routers for Django Rest Framework
(alanjds/drf-nested-routers)pyleoclim_util
47 IssuesPython Package for the Analysis of Paleoclimate Data. Documentation at
(linkedearth/pyleoclim_util)ics-py
47 IssuesPythonic and easy iCalendar library (rfc5545)
(ics-py/ics-py)caura-memclaw
47 IssuesGoverned shared memory for AI agent fleets — multi-agent, multi-tenant, MCP-native. Trust tiers, keystone policies, audit trails, knowledge graph, self-improving retrieval. Apache 2.0.
(caura-ai/caura-memclaw)ncbi-genome-download
47 IssuesScripts to download genomes from the NCBI FTP servers
(kblin/ncbi-genome-download)errbot
47 IssuesErrbot is a chatbot, a daemon that connects to your favorite chat service and bring your tools and some fun into the conversation.
(errbotio/errbot)sdk-python
47 IssuesTemporal Python SDK
(temporalio/sdk-python)grok-1
46 IssuesGrok open release
(xai-org/grok-1)jc
46 IssuesCLI tool and python library that converts the output of popular command-line tools, file-types, and common strings to JSON, YAML, or Dictionaries. This allows piping of output to tools like jq and simplifying automation scripts.
(kellyjonbrazil/jc)combine
45 IssuesTool to gather Threat Intelligence indicators from publicly available sources
(mlsecproject/combine)code-review-graph
45 IssuesLocal-first code intelligence graph for MCP and CLI. Builds a persistent map of your codebase so AI coding tools read only what matters, with benchmarked context reductions on reviews and large-repo workflows.
(tirth8205/code-review-graph)meowth
45 IssuesA Discord helper bot for Pokemon Go communities.
(foglyogly/meowth)jasmin
45 IssuesJasmin - Open source SMS gateway
(jookies/jasmin)grid
43 IssuesPython library for numerical integration, interpolation, and differentiation on (molecular) grids.
(theochem/grid)flask-googlemaps
43 IssuesEasy way to add GoogleMaps to Flask applications. maintainer: @getcake
(flask-extensions/flask-googlemaps)django-admin2
43 IssuesExtendable, adaptable rewrite of django.contrib.admin
(jazzband/django-admin2)bugwarrior
43 IssuesPull github, bitbucket, and trac issues into taskwarrior
(ralphbean/bugwarrior)pyswarms
42 IssuesA research toolkit for particle swarm optimization in Python
(ljvmiranda921/pyswarms)openmanage-enterprise
42 IssuesScript collateral leveraging the OME REST API
(dell/openmanage-enterprise)plone.api
42 IssuesThe Plone API
(plone/plone.api)websauna
41 IssuesWebsauna is a full stack Python web framework for building web services and back offices with admin interface and sign up process
(websauna/websauna)